Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

The nonsteroidal mineralocorticoid receptor antagonist finerenone has been reported to improve kidney and cardiovascular outcomes in persons with type 2 diabetes and chronic kidney disease (CKD).

Recent FDA actions related to leucovorin have caused confusion. There is still a lack of scientific evidence establishing that the drug is a safe and effective treatment for autism.

Patients with atrial fibrillation and a moderate-to-high risk of stroke were randomly assigned, in a 1:1:1 ratio, to receive subcutaneous injection of abelacimab (150 mg or 90 mg once monthly) ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

The Indianapolis Health Equity, Access, Outreach, and Treatment Collaborative was designed to help patients build the knowledge, skills, and support needed to manage their cardiovascular health.

To the Editor: Morin and Buysse (July 18 issue) 1 provide a comprehensive overview of current assessments and treatments for insomnia. Their emphasis on cognitive behavioral therapy for insomnia as a ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 23).

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality in ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 5).