DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

During a session hosted by the Division of Biochemistry and Chemical Biology (BIOL), Wei Sun, a chemical biologist at ...

Chemical cross-linking (XL) is widely used to investigate protein–protein interactions (PPIs), including transient or low ...

Data from a new study in mice connects unrepaired DNA-protein crosslinks (DPCs), highly toxic tangles of protein and DNA, to inflammation-linked premature aging and embryonic lethality in mice. The ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice. The findings reveal a previously ...

Tunable DNA hairpin springs stretch millions of protein copies under piconewton tension, enabling bulk biochemical discovery ...

A protein tied to ALS and dementia may have a much bigger role in disease than scientists realized. Researchers found that ...