WebMD

Thymidine Kinase 2 Deficiency (TK2d)

What Is Thymidine Kinase 2 Deficiency (TK2d)? Thymidine kinase 2 deficiency (TK2d) mainly causes muscle weakness. It’s a very rare mitochondrial disease. Mitochondria are tiny organ-like structures ...
Monthly Prescribing Reference

FDA Approves Kygevvi for Thymidine Kinase 2 Deficiency

Kygevvi is expected to be commercially available in the US in the first quarter of 2026. The Food and Drug Administration (FDA) has approved Kygevvi ® for the treatment of thymidine kinase 2 ...
PharmTech

EMA Recommends Kygevvi for Rare Thymidine Kinase 2 Deficiency Treatment

Kygevvi, a combination of doxecitine and doxribtimine, is recommended by the EMA for TK2d treatment in young patients. The treatment addresses genetic pathology by supplementing deoxypyrimidine ...
ascopubs.org

Glucarpidase, Leucovorin, and Thymidine for High-Dose Methotrexate-Induced Renal Dysfunction: Clinical and Pharmacologic Factors Affecting Outcome

Clinical Value of Fluorine-18 2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography in Bladder Cancer Patients with HDMTX-induced nephrotoxicity received one to three doses of ...